CHEM 455
Synthesis and Qualitative Organic Analysis
Chemistry and Biochemistry
College of Physical and Mathematical Sciences
Course Description
Laboratory course emphasizing isolation, purification, and characterization of major and minor products from selected syntheses.
When Taught
Fall
Grade Rule
Grade Rule 8: A, B, C, D, E, I (Standard grade rule)
Min
4
Fixed
4
Fixed
2
Fixed
6
Other Prerequisites
Chem 201 or concurrent enrollment
Note
For chemistry and other science majors.
Title
Completion of Reactions
Learning Outcome
Monitor and evaluate the successful completion of reactions using TLC with various solvents and modes, solvent changes and co-spot interpretation.
Title
NMR Theory
Learning Outcome
Demonstrate understanding of NMR theory including magnetic field resonance, radio frequency pulse sequences, shift, splitting, polarization transfer, signal correlation, 2D experiments including homo and heterocorrelation spectroscopy, COSY, HSQC, NOESY, and multiple bond techniques, HMBC, TOCSY
Title
Polarimetry Theory
Learning Outcome
Demonstrate understanding of polarimetry theory including plane polarized light, interaction with chiral compounds, optical rotation and determination of enantiomeric excess.
Title
Design New Reactions to Obtain Desired Products
Learning Outcome
Critically evaluate literature references, in particular experimental reaction details including reagents, starting materials, solvent, temperature, apparatus, stoichiometry, and scale. Adapt and modify known procedures to design and execute new reactions to obtain desired products on small and moderate scales (mg–g).
Title
MS Theory
Learning Outcome
Demonstrate understanding of MS theory including ionization techniques, EI, CI, FAB, ES, MALDI, detection techniques, fragmentation patterns of functional groups, molecular ion, base peak, isotopes, N-rule.
Title
Basic Purification
Learning Outcome
Perform basic purification operations using recrystallization, distillation, chromatography with proper choice of solvents, techniques, mode of operation, etc. based on the properties of the product compound.
Title
Hands on Operation
Learning Outcome
Evaluate purity and identification of structures using hands on operation of NMR, IR, MS, and polarimetry.
Title
Reactions Using Appropriate Systems
Learning Outcome
Work up reactions using the appropriate organic and aqueous system based on polarity and acid/base properties including drying and solvent removal operations.
Title
Write Clear Lab Reports
Learning Outcome
Write clear lab reports including clear experimental detail, operation, characterization, interpretation, evaluation, and conclusions.
Title
Complete Peak Assignment
Learning Outcome
Prepare sample, set up and obtain routine 1D 1H and 13C NMR spectra showing adequate signal locking, shimming, formatting, data processing, spectra interpretation with complete peak assignment.
