CHEM 468

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Biophysical Chemistry

Chemistry and Biochemistry College of Computational, Mathematical, & Physical Sciences

Course Description

Applications of physical chemistry to biological systems. Spectroscopic applications, computational methods, structural biochemistry, thermodynamics, equilibria, statistical mechanics, transport properties, kinetics, quantum mechanics.

When Taught

Winter

Min

3

Fixed

3

Fixed

3

Fixed

0

Note

For biochemistry (BS) majors and those interested in the health professions or biochemistry.

Title

Fundamental Concepts in Four Principal Areas

Learning Outcome

Describe conceptually the fundamental concepts in the four principal areas of physical chemistry: classical thermodynamics, statistical thermodynamics kinetics and quantum mechanics

Title

Define and Manipulate Concepts Mathematically

Learning Outcome

Define mathematically the concepts outlined in 1) and manipulate the fundamental and derived equations associated with these concepts

Title

Use Skills to Calculate or Predict Conditions

Learning Outcome

Use the above skills to calculate or predict the equilibrium conditions or direction of spontaneous biochemical processes that are involved in metabolism or energy transfer events given appropriate thermodynamic data and initial system conditions

Title

Mathematical and Graphical Techniques

Learning Outcome

Employ mathematical and graphical techniques on enzyme kinetic data to extract key parameters and to identify inhibition mechanisms

Title

Solve Schroedinger Equation Problems

Learning Outcome

Solve simple Schroedinger equation problems (e.g., particle in a box), identify boundary conditions, and explain the significance of boundary conditions on the observance of quantized effects

Title

Predictions of Behavior

Learning Outcome

Relate the simple Hamiltonians from above to biological molecules and systems and generalize from the simple results to make predictions regarding behavior in the biological systems

Title

Nature of Electronic Energy Levels

Learning Outcome

Identify the nature of electronic energy levels in key photoactive biological molecules and use spectroscopic data to probe these levels

Title

Apply Concepts to Photosynthesis and Vision

Learning Outcome

Apply fundamental concepts of electronic structure and reaction kinetics to the steps in photosynthesis and vision

Title

Physical Chemistry Perspectives Lead to Deeper Understanding

Learning Outcome

Provide examples in which physical chemistry perspectives have enabled a deeper more complete understanding of the structure and function of biological molecules and complex biological systems